Novel dual-acting nitroxide-based hybrid antioxidants
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Komba Thomas Thesis (PDF 3MB) |
Description
This project employed a rational drug design and development approached to make hybrid dual-acting antioxidants as potential medications for managing chronic inflammation and oxidative stress-related diseases such as arthritis and Parkinson disease. The approach (pharmacophore hybridization strategy) combined various nitroxide compounds with known drugs - mainly the NSAID and sympathomimetic stimulants class of drugs. The hybrid compounds developed in this project displayed promising therapeutic actions as antioxidant, anti-inflammatory and anticancer agents.
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| ID Code: | 97691 |
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| Item Type: | QUT Thesis (PhD) |
| Supervisor: | Bottle, Steven & Fairfull-Smith, Kathryn |
| Keywords: | Nitroxides, Antioxidant, Catechols, Oxidative Stress, Chronic Inflammation, Paramagnetic Broadening, Site Directed Spin Label, Synthesis, Schöllkopf, Nonsteroidal Anti-inflammatory Drugs, Pharmacophore Hybridization |
| Divisions: | Past > QUT Faculties & Divisions > Science & Engineering Faculty Past > Schools > School of Chemistry, Physics & Mechanical Engineering |
| Institution: | Queensland University of Technology |
| Deposited On: | 09 Aug 2016 01:21 |
| Last Modified: | 08 Sep 2017 14:51 |
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