Magnetic resonance imaging of the anulus fibrosus shows changes in tissue diffusion and anisotropy following mechanical loading: A pilot study in ovine tissue
Tourell, Monique C., Kirkwood, Margaret, Momot, Konstantin I., Pearcy, Mark J., & Little, J. Paige (2016) Magnetic resonance imaging of the anulus fibrosus shows changes in tissue diffusion and anisotropy following mechanical loading: A pilot study in ovine tissue. In Spineweek 2016, 2016-05-16 - 2016-05-20. (Unpublished)
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MRI_AF_Abstract.pdf. |
Description
Prior investigations of disc mechanics have suggested the existence of a ‘derangement’ strain, whereby loading beyond this strain results in damage to the anulus fibrosus ground substance. The current pilot study sought to explore the functional micro-mechanics of the anulus fibrosus using both imaging and experimental methods, in order to better understand the underlying mechanisms which govern the interplay between disc mechanical function and microstructure. A comparison of MRI diffusion tensor imaging of anulus fibrosus samples before and after mechanical testing showed clear changes in diffusivity, indicating the tissue becomes more anisotropic following mechanical testing. This increase in anisotropy is possibly due to the collagen fibres becoming more aligned.
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| ID Code: | 97857 | ||||||
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| Item Type: | Contribution to conference (Poster) | ||||||
| Refereed: | Yes | ||||||
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| Keywords: | anisotropy, anulus fibrosis, derangement strain, diffusion tensor imaging, disc mechanics, disc microstructure, magnetic resonance imaging, mechanical loading, ovine, ovine intervertebral disc, tissue diffusion | ||||||
| Pure ID: | 57290118 | ||||||
| Divisions: | Past > Institutes > Institute of Health and Biomedical Innovation Past > QUT Faculties & Divisions > Science & Engineering Faculty Current > Research Centres > Australian Research Centre for Aerospace Automation |
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| Copyright Owner: | 2016 The Authors | ||||||
| Copyright Statement: | This work is covered by copyright. Unless the document is being made available under a Creative Commons Licence, you must assume that re-use is limited to personal use and that permission from the copyright owner must be obtained for all other uses. If the document is available under a Creative Commons License (or other specified license) then refer to the Licence for details of permitted re-use. It is a condition of access that users recognise and abide by the legal requirements associated with these rights. If you believe that this work infringes copyright please provide details by email to qut.copyright@qut.edu.au | ||||||
| Deposited On: | 02 Aug 2016 22:41 | ||||||
| Last Modified: | 08 Feb 2025 06:04 |
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