?url_ver=Z39.88-2004&rft_id=10.5204%2Fthesis.eprints.103844&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=Regulation+of+human+neural+stem+cell+fate+determination+by+proteoglycans&rft.creator=Oikari%2C+Lotta+Emilia&rft.subject=Neural+stem+cell&rft.subject=Heparan+sulfate+proteoglycan&rft.subject=Neurogenesis&rft.subject=Neuron&rft.subject=Astrocyte&rft.subject=Syndecan&rft.subject=Glypican&rft.subject=Extracellular+matrix&rft.description=This+thesis+investigated+how+human+neural+stem+cells+are+regulated%2C+focusing+specifically+on+heparan+sulfate+proteoglycans%2C+the+key+proteins+of+the+extracellular+space.+The+findings+of+this+study+identified+central+roles+for+proteoglycans+in+mediating+neural+stem+cell+events%2C+including+self-renewal+and+differentiation.+This+research+has+improved+our+understanding+of+human+stem+cell+and+human+neurogenesis+biology+and+provided+novel+approaches+for+the+development+of+improved+neural+stem+cell+applications%2C+including+using+these+cells+for+brain+damage+therapy.&rft.publisher=Queensland+University+of+Technology&rft.date=2017&rft.type=Thesis&rft.format=application%2Fpdf&rft.relation=https%3A%2F%2Feprints.qut.edu.au%2F103844%2F8%2FLotta_Emilia_Oikari_Thesis.pdf&rft.rights=free_to_read&rft.relation=doi%3A10.5204%2Fthesis.eprints.103844&rft.relation=Oikari%2C+Lotta+Emilia+(2017)+Regulation+of+human+neural+stem+cell+fate+determination+by+proteoglycans.+PhD+thesis%2C+Queensland+University+of+Technology.&rft.id_number=https%3A%2F%2Feprints.qut.edu.au%2F103844%2F&rft.identifier=Faculty+of+Health%3B+Institute+of+Health+and+Biomedical+Innovation%3B+School+of+Biomedical+Sciences