?url_ver=Z39.88-2004&rft_id=10.5204%2Fthesis.eprints.103955&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=Serotonin+and+noradrenaline+signalling+in+binge-like+long-term+alcohol+intake+and+associated+maladaptive+effects+in+adult+mice&rft.creator=Patkar%2C+Omkar+Laxman&rft.subject=long-term&rft.subject=binge-like&rft.subject=alcohol&rft.subject=noradrenaline&rft.subject=serotonin&rft.subject=pindolol&rft.subject=tandospirone&rft.subject=synaptic+triads&rft.description=Alcohol+dependence+is+a+debilitating+disorder+with+current+therapies+displaying+limited+efficacy+and%2For+compliance.+This+thesis+investigated+the+contribution+of+two+key+neurotransmitters%3B+noradrenaline+and+serotonin+in+alcohol+dependence+using+a+mouse+model+of+binge-like+alcohol+consumption.+Using+this+model%2C+the+study+demonstrated+that+long-term+alcohol+intake+causes+neuroadaptive+changes+in+the+signalling+of+these+molecules+leading+to+alterations+in+normal+emotional+states+and+alcohol+dependence.+Finally%2C+the+thesis+highlighted+the+efficacy+of+the+FDA+approved+drug+for+hypertension+pindolol+and+the+anxiolytic+drug+tandospirone+to+reduce+alcohol+consumption%2C+thereby+offering+a+novel+approach+to+improve+treatments+for+alcohol+addiction.&rft.publisher=Queensland+University+of+Technology&rft.date=2017&rft.type=Thesis&rft.format=application%2Fpdf&rft.relation=https%3A%2F%2Feprints.qut.edu.au%2F103955%2F1%2FOmkar%2520Laxman_Patkar_Thesis.pdf&rft.rights=free_to_read&rft.relation=doi%3A10.5204%2Fthesis.eprints.103955&rft.relation=Patkar%2C+Omkar+Laxman+(2017)+Serotonin+and+noradrenaline+signalling+in+binge-like+long-term+alcohol+intake+and+associated+maladaptive+effects+in+adult+mice.+PhD+by+Publication%2C+Queensland+University+of+Technology.&rft.id_number=https%3A%2F%2Feprints.qut.edu.au%2F103955%2F&rft.identifier=Faculty+of+Health%3B+Institute+of+Health+and+Biomedical+Innovation%3B+School+of+Clinical+Sciences