?url_ver=Z39.88-2004&rft_id=10.5204%2Fthesis.eprints.118142&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=Investigating+the+role+of+neuronal+nicotinic+acetylcholine+receptor+subtypes+in+the+acquisition+and+maintenance+of+alcohol+use+disorders&rft.creator=Tarren%2C+Josephine+R.&rft.subject=alcohol&rft.subject=nAChR&rft.subject=CHRNA4&rft.subject=nucleus+accumbens&rft.subject=amygdala&rft.subject=varenicline&rft.subject=addiction&rft.subject=pre-frontal+cortex&rft.subject=early+life+stress&rft.subject=nicotine&rft.description=Owing+to+the+substantial+comorbidity+of+nicotine+and+alcohol%2C+this+project+was+designed+to+explore+the+role+that+neuronal+nicotinic+acetylcholine+receptors+play+in+the+development+of+alcohol+use+disorders.+This+study+utilised+well-established+animal+models%2C+documenting+the+impact+of+'binge-like'+ethanol+consumption+on+the+expression+of+these+receptors+in+key+brain+areas+governing+stress+and+reward.+Only+by+continuing+to+uncover+the+neurological+changes+attributed+to+alcohol+consumption%2C+can+we+further+elucidate+treatment+options+for+those+affected.&rft.publisher=Queensland+University+of+Technology&rft.date=2018&rft.type=Thesis&rft.format=application%2Fpdf&rft.relation=https%3A%2F%2Feprints.qut.edu.au%2F118142%2F1%2FJosephine_Tarren_Thesis.pdf&rft.rights=free_to_read&rft.relation=doi%3A10.5204%2Fthesis.eprints.118142&rft.relation=Tarren%2C+Josephine+R.+(2018)+Investigating+the+role+of+neuronal+nicotinic+acetylcholine+receptor+subtypes+in+the+acquisition+and+maintenance+of+alcohol+use+disorders.+PhD+by+Publication%2C+Queensland+University+of+Technology.&rft.id_number=https%3A%2F%2Feprints.qut.edu.au%2F118142%2F&rft.identifier=Faculty+of+Health%3B+School+of+Clinical+Sciences