?url_ver=Z39.88-2004&rft_id=10.5204%2Fthesis.eprints.135713&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=Delineating+the+role+of+Hepatocyte+nuclear+factor+1+beta+(HNF1B)+transcript+variants+in+prostate+cancer&rft.creator=Chandra%2C+Shubhra&rft.subject=Genome+wide+association+studies+(GWAS)&rft.subject=Hepatocyte+nuclear+factor+1+beta+(HNF1B)&rft.subject=single+nucleotide+polymorphisms+(SNPs)&rft.subject=Prostate+Cancer+(PCa)&rft.subject=Splice+variants&rft.description=Genome+Wide+Association+Studies+(GWAS)+has+identified+HNF1B+located+at+chromosome+17q12+as+foremost+risk+gene+for+prostate+cancer+susceptibility+in+multi-ethnic+populations.+This+thesis+characterises+the+HNF1B+transcript+variants+along+with+defining+their+expression+pattern+and+functional+attributes+in+prostate+cancer.+Future+research+will+enable+the+discovery+of+the+molecular+mechanism+of+their+actions+and+whether+targeting+these+HNF1B+transcript+variants+in+cancer+may+prove+a+useful+therapeutic+strategy.&rft.publisher=Queensland+University+of+Technology&rft.date=2020&rft.type=Thesis&rft.format=application%2Fpdf&rft.relation=https%3A%2F%2Feprints.qut.edu.au%2F135713%2F1%2FShubhra_Chandra_Thesis.pdf&rft.rights=free_to_read&rft.rights=http%3A%2F%2Fcreativecommons.org%2Flicenses%2Fby-nc-nd%2F4.0%2F&rft.relation=doi%3A10.5204%2Fthesis.eprints.135713&rft.relation=Chandra%2C+Shubhra+(2020)+Delineating+the+role+of+Hepatocyte+nuclear+factor+1+beta+(HNF1B)+transcript+variants+in+prostate+cancer.+Master+of+Philosophy+thesis%2C+Queensland+University+of+Technology.&rft.id_number=https%3A%2F%2Feprints.qut.edu.au%2F135713%2F&rft.identifier=Faculty+of+Health%3B+School+of+Biomedical+Sciences