?url_ver=Z39.88-2004&rft_id=10.5204%2Fthesis.eprints.200151&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=Expression%2C+function%2C+and+regulation+of+two+key+genes+involved+in+prostate+cancer+metabolism&rft.creator=Subramaniam%2C+Sugarniya&rft.subject=Prostate+cancer&rft.subject=pyruvate+dehydrogenase+kinase+1&rft.subject=malonyl-CoA-acyl+carrier+protein+transacylase&rft.subject=microRNA&rft.subject=miRSNP&rft.subject=metabolism&rft.subject=glycolysis&rft.subject=lipogenesis&rft.subject=hypoxia&rft.subject=androgen&rft.description=Metabolic+deregulation+is+an+emergent+hallmark+of+prostate+cancer+and+studies+show+that+altered+patterns+of+metabolic+pathways+involved+in+the+development+of+malignancy.+A+large+genetic+association+on+microRNA+(miRNA)+related+genetic+variations+recently+identified+single+nucleotide+polymorphisms+(SNPs)+in+two+key+metabolic+genes.+This+thesis+analysed+the+role+of+metabolic+genes+and+functional+validation+of+SNPs+and+associated+miRNAs+involved+in+the+regulation+of+these+genes+as+a+mediator+of+prostate+cancer+aetiology.+The+findings+from+this+study+suggest+that+studies+of+miRNAs+and+their+interactions+with+SNPs+could+provide+valuable+insights+into+the+complicated+mechanisms+of+prostate+cancer+risk+and+identify+suitable+molecular+pathways+for+targeted+therapy.&rft.publisher=Queensland+University+of+Technology&rft.date=2020&rft.type=Thesis&rft.format=application%2Fpdf&rft.relation=https%3A%2F%2Feprints.qut.edu.au%2F200151%2F1%2FSugarniya_Subramaniam_Thesis.pdf&rft.rights=free_to_read&rft.rights=http%3A%2F%2Fcreativecommons.org%2Flicenses%2Fby-nc-nd%2F4.0%2F&rft.relation=doi%3A10.5204%2Fthesis.eprints.200151&rft.relation=Subramaniam%2C+Sugarniya+(2020)+Expression%2C+function%2C+and+regulation+of+two+key+genes+involved+in+prostate+cancer+metabolism.+PhD+thesis%2C+Queensland+University+of+Technology.&rft.id_number=https%3A%2F%2Feprints.qut.edu.au%2F200151%2F&rft.identifier=Faculty+of+Health%3B+School+of+Biomedical+Sciences