?url_ver=Z39.88-2004&rft_id=10.5204%2Fthesis.eprints.212448&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=Dissecting+the+role+of+tissue-specific+cancer-associated+fibroblasts+in+the+prostate+tumour+microenvironment&rft.creator=Jaeschke%2C+Anna&rft.subject=cancer-associated+fibroblasts&rft.subject=prostate+cancer&rft.subject=tumour+microenvironment&rft.subject=tumour+models&rft.subject=bioengineered+cancer+models&rft.description=Much+of+what+we+know+today+about+prostate+cancer+is+derived+from+studying+cancer+cells+grown+on+a+2D+plastic+substrate%2C+not+representing+the+complex+structure+of+a+three-dimensional+tumour.+In+this+work%2C+bioengineered+cancer+models+provided+physiologically+relevant+research+platforms+to+gain+novel+insights+into+the+interactions+between+different+cell+types+present+in+the+tumour.+Distinct+features+of+the+cancerous+and+healthy+tissues+were+found+that+have+the+potential+to+be+explored+for+new+diagnostic+approaches.+Advanced+toolkits+were+developed+to+support+the+use+of+bioengineered+models+to+their+full+potential%2C+and+to+be+utilised+for+further+research+questions.&rft.publisher=Queensland+University+of+Technology&rft.date=2021&rft.type=Thesis&rft.format=application%2Fpdf&rft.relation=https%3A%2F%2Feprints.qut.edu.au%2F212448%2F1%2FAnna%2520Jaeschke%2520Thesis.pdf&rft.rights=free_to_read&rft.rights=http%3A%2F%2Fcreativecommons.org%2Flicenses%2Fby-nc-nd%2F4.0%2F&rft.relation=doi%3A10.5204%2Fthesis.eprints.212448&rft.relation=Jaeschke%2C+Anna+(2021)+Dissecting+the+role+of+tissue-specific+cancer-associated+fibroblasts+in+the+prostate+tumour+microenvironment.+PhD+by+Publication%2C+Queensland+University+of+Technology.&rft.id_number=https%3A%2F%2Feprints.qut.edu.au%2F212448%2F&rft.identifier=Faculty+of+Engineering%3B+School+of+Mechanical%2C+Medical+%26+Process+Engineering