?url_ver=Z39.88-2004&rft_id=10.5204%2Fthesis.eprints.230762&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=Numerical+methods+for+optimal+control+and+parameter+estimation+in+the+life+sciences&rft.creator=Sharp%2C+Jesse+A.&rft.subject=Optimal+control&rft.subject=Systems+biology&rft.subject=Numerical+methods&rft.subject=Forward-backward+sweep+method&rft.subject=Information+geometry&rft.subject=Uncertainty+quantification&rft.subject=Acute+myeloid+leukaemia&rft.subject=Chemotherapy&rft.subject=Convergence+acceleration&rft.subject=Pontryagin+Maximum+Principle&rft.description=This+thesis+concerns+numerical+methods+in+mathematical+optimisation+and+inference%3B+with+a+focus+on+techniques+for+optimal+control%2C+and+for+parameter+estimation+and+uncertainty+quantification.+Novel+methodological+and+computational+developments+are+presented%2C+with+a+view+to+improving+the+efficiency%2C+effectiveness+and+accessibility+of+these+techniques+for+practitioners.+The+numerical+methods+considered+in+this+work+are+widely+applied+throughout+the+life+sciences%3B+in+areas+including+ecology%2C+epidemiology+and+oncology%2C+and+beyond+the+life+sciences%3B+in+engineering%2C+economics%2C+aeronautics+and+other+disciplines.&rft.publisher=Queensland+University+of+Technology&rft.date=2022&rft.type=Thesis&rft.format=application%2Fpdf&rft.relation=https%3A%2F%2Feprints.qut.edu.au%2F230762%2F8%2FJesse_Sharp_Thesis_.pdf&rft.rights=free_to_read&rft.rights=http%3A%2F%2Fcreativecommons.org%2Flicenses%2Fby-nc-nd%2F4.0%2F&rft.relation=doi%3A10.5204%2Fthesis.eprints.230762&rft.relation=Sharp%2C+Jesse+A.+(2022)+Numerical+methods+for+optimal+control+and+parameter+estimation+in+the+life+sciences.+PhD+by+Publication%2C+Queensland+University+of+Technology.&rft.id_number=https%3A%2F%2Feprints.qut.edu.au%2F230762%2F&rft.identifier=Faculty+of+Science%3B+School+of+Mathematical+Sciences