?url_ver=Z39.88-2004&rft_id=10.5204%2Fthesis.eprints.236375&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=The+Microwell-mesh+platform%3A+A+multifaceted+microtissue+technology+to+link+cell+culture%2C+animal+models+and+patients&rft.creator=Monterossi%2C+Melissa+Eileen&rft.subject=3D+Culture&rft.subject=microtissue&rft.subject=mesenchymal+stem+cells+MSC&rft.subject=bone+marrow+mesenchymal+stem+cells+BMSC&rft.subject=bone+repair&rft.subject=patient+derived+xenograft+PDX&rft.subject=prostate+cancer&rft.subject=primary+cells&rft.subject=regenerative+therapies&rft.subject=translational+research&rft.description=Work+towards+effective+translational+medicine+has+revealed+that+current+in+vitro+platforms+are+not+sufficient+to+produce+relevant+clinical+results.+Advances+in+3D+technologies+and+preclinical+models+must+be+made+to+address+the+gaps+lead+to+failure+of+initially+promising+therapies.+The+Microwell-mesh+platform+is+a+versatile+device+demonstrated+to+help+bridge+this+gap.+The+device+within+the+context+of+completed+work+was+used+to+not+only+generate+cancer+xenograft+models%2C+crucial+for+successful+personalized+cancer+therapeutics%2C+but+was+also+used+to+investigate+the+capacity+of+adult+mesenchymal+stem+cells+to+regenerate+bone+and+cartilage+tissues+within+relevant+biological+environments.&rft.publisher=Queensland+University+of+Technology&rft.date=2022-11-14&rft.type=Thesis&rft.format=application%2Fpdf&rft.relation=https%3A%2F%2Feprints.qut.edu.au%2F236375%2F1%2FMelissa_Monterosso_Thesis.pdf&rft.rights=free_to_read&rft.rights=http%3A%2F%2Fcreativecommons.org%2Flicenses%2Fby-nc-nd%2F4.0%2F&rft.relation=doi%3A10.5204%2Fthesis.eprints.236375&rft.relation=Monterossi%2C+Melissa+Eileen+(2022)+The+Microwell-mesh+platform%3A+A+multifaceted+microtissue+technology+to+link+cell+culture%2C+animal+models+and+patients.+PhD+thesis%2C+Queensland+University+of+Technology.&rft.id_number=https%3A%2F%2Feprints.qut.edu.au%2F236375%2F&rft.identifier=Faculty+of+Health%3B+School+of+Biomedical+Sciences