?url_ver=Z39.88-2004&rft_id=10.5204%2Fthesis.eprints.241970&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=Impact+of+genetic+polymorphisms+on+the+cancer+risk%2C+alternative+splicing%2C+and+miRNA+expression&rft.creator=Moradi%2C+Afshin&rft.subject=Short+tandem+repeats&rft.subject=isomiR&rft.subject=alternative+splicing&rft.subject=prostate+cancer&rft.subject=miRNA&rft.description=The+abnormal+growth+of+cells+in+the+prostate+gland+is+what+causes+prostate+cancer+(PrCa).+Short+tandem+repeats+(STRs)+consist+of+1%E2%80%936+bp+motifs+repeated+in+tandem.+We+analysed+STR+at+the+genome-wide+level+to+find+STR+associated+with+PrCa%2C+gene%2C+and+miRNA+expression.+Moreover%2C+we+investigated+the+effect+of+SNPs+on+alternative+splicing+(AS)+and+isomiR+expression.+We+found+PrCa-associated+isomiR+and+splice+variants.+We+developed+a+user-friendly+web+interface%2C+isomiR-eQTL%2C+that+provides+resources+and+comprehensive+analysis+outcomes+on+the+genetic+mechanisms+of+miRNA+and+isomiR+regulation.&rft.publisher=Queensland+University+of+Technology&rft.date=2023-07-17&rft.type=Thesis&rft.format=application%2Fpdf&rft.relation=https%3A%2F%2Feprints.qut.edu.au%2F241970%2F1%2FAfshin%252BMoradi%252BThesis.pdf&rft.rights=free_to_read&rft.rights=http%3A%2F%2Fcreativecommons.org%2Flicenses%2Fby-nc-nd%2F4.0%2F&rft.relation=doi%3A10.5204%2Fthesis.eprints.241970&rft.relation=Moradi%2C+Afshin+(2023)+Impact+of+genetic+polymorphisms+on+the+cancer+risk%2C+alternative+splicing%2C+and+miRNA+expression.+PhD+by+Publication%2C+Queensland+University+of+Technology.&rft.id_number=https%3A%2F%2Feprints.qut.edu.au%2F241970%2F&rft.identifier=Faculty+of+Health%3B+School+of+Biomedical+Sciences