?url_ver=Z39.88-2004&rft_id=10.5204%2Fthesis.eprints.242343&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=The+functional+role+of+a+GWAS+identified+microRNA+in+prostate+cancer&rft.creator=Lalkota%2C+Bhanu+Prakash&rft.subject=Prostate+cancer&rft.subject=microRNA&rft.subject=miRNA&rft.subject=replacement+therapy&rft.subject=Functional+role&rft.subject=miRNA+mimics&rft.subject=Predictive+drugs&rft.subject=Tumour+suppressor&rft.description=MicroRNAs+(miRNAs)+are+small+RNA+species+that+act+as+master+regulators+in+cancer+by+simultaneous+regulation+of+multiple+genes.+In+cancer+cells%2C+the+lack+of+natural+miRNA+function+and+consequent+uncontrolled+oncogene+expression+leads+to+tumorigenesis.+This+study+aimed+to+analyse+the+functional+role+of+a+specific+miRNA%2C+shorlisted+via+previous+genetic+association+study.+Stable+overexpression+cell+lines+harboring+this+miRNA+were+established%2C+and+its+functional+role+was+confirmed+using+cell+proliferation%2C+migration+and+invasion+assays.+Moreover%2C+in+vivo+analyses+confirmed+the+potential+of+our+shortlisted+miRNA+for+the+%22miRNA+replacement+therapy%22+to+treat+prostate+cancer.&rft.publisher=Queensland+University+of+Technology&rft.date=2023-08-11&rft.type=Thesis&rft.format=application%2Fpdf&rft.relation=https%3A%2F%2Feprints.qut.edu.au%2F242343%2F1%2FBhanu%252BLalkota%252BThesis%25283%2529.pdf&rft.rights=free_to_read&rft.rights=http%3A%2F%2Fcreativecommons.org%2Flicenses%2Fby-nc-nd%2F4.0%2F&rft.relation=doi%3A10.5204%2Fthesis.eprints.242343&rft.relation=Lalkota%2C+Bhanu+Prakash+(2023)+The+functional+role+of+a+GWAS+identified+microRNA+in+prostate+cancer.+Master+of+Philosophy+thesis%2C+Queensland+University+of+Technology.&rft.id_number=https%3A%2F%2Feprints.qut.edu.au%2F242343%2F&rft.identifier=Faculty+of+Health%3B+School+of+Biomedical+Sciences