?url_ver=Z39.88-2004&rft_id=10.5204%2Fthesis.eprints.248849&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=Investigating+the+role+of+mitochondrial+energy+rewiring+throughout+prostate+cancer+progression&rft.creator=Bidgood%2C+Charles&rft.subject=Prostate+Cancer&rft.subject=Metabolism&rft.subject=Androgen+Targeted+Therapies&rft.subject=Branched-Chain+Amino+Acids&rft.subject=Valine+Catabolism&rft.subject=3-Hydroxyisobutyryl-CoA+Hydrolase&rft.subject=Oncology&rft.subject=Molecular+Biology&rft.subject=Biochemistry&rft.subject=Fluorescence+Microscopy&rft.description=Prostate+cancer+is+the+most+commonly+diagnosed+non-cutaneous+cancer+in+men.+Despite+effective+first-line+therapies%2C+approximately+30%25+of+patients+will+recur+with+advanced+disease%2C+highlighting+an+unmet+clinical+burden.+This+project+investigated+the+role+of+mitochondrial+plasticity+within+the+progression+of+prostate+cancer+and+within+the+onset+of+therapeutic+resistance+to+commonly+prescribed+androgen+targeted+medications.+As+a+result+of+the+work+performed+in+this+thesis%2C+we+have+identified+a+key+metabolic+pathway+driving+advanced+prostate+cancer+progression+and+propose+novel+therapeutic+strategies+which+inhibits+an+enzyme+critical+to+this+molecular+adaption.&rft.publisher=Queensland+University+of+Technology&rft.date=2023-05-23&rft.type=Thesis&rft.format=application%2Fpdf&rft.relation=https%3A%2F%2Feprints.qut.edu.au%2F248849%2F1%2FCharles%252BBidgood%252BThesis.pdf&rft.rights=free_to_read&rft.rights=http%3A%2F%2Fcreativecommons.org%2Flicenses%2Fby-nc-nd%2F4.0%2F&rft.relation=doi%3A10.5204%2Fthesis.eprints.248849&rft.relation=Bidgood%2C+Charles+(2023)+Investigating+the+role+of+mitochondrial+energy+rewiring+throughout+prostate+cancer+progression.+PhD+thesis%2C+Queensland+University+of+Technology.&rft.id_number=https%3A%2F%2Feprints.qut.edu.au%2F248849%2F&rft.identifier=Faculty+of+Health%3B+School+of+Biomedical+Sciences