?url_ver=Z39.88-2004&rft_id=10.5204%2Fthesis.eprints.249038&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=A+3D+printed+hydrogel+microfluidic+vascular+model+for+studying+the+interplay+between+atherogenic+hemodynamics+and+vascular+cells&rft.creator=Amaya+Catano%2C+Jorge+Alberto&rft.subject=Atherosclerosis&rft.subject=hemodynamics&rft.subject=vascular+models&rft.subject=shear+stress&rft.subject=3D+printing&rft.subject=GelMA+hydrogel&rft.subject=tissue+engineering&rft.subject=perfused+cell+culture&rft.subject=medical+image+segmentation&rft.subject=cardiovascular+diseases&rft.description=This+work+presents+a+new+approach+for+patient-specific+vascular+models%2C+capturing+anatomy%2C+hemodynamic%2C+and+cell+arrangement.+MRI+images+were+utilized+to+create+3D+models+of+carotid+vessel+bifurcations.+Computational+fluid+dynamics+was+employed+to+investigate+hemodynamics.+Replicas+of+the+carotid+vessel+were+produced+via+3D-DLP+bioprinting%2C+resembling+cellular+organization+with+embedded+human+smooth+muscle+cells+and+seeded+endothelial+cells.+The+study+demonstrated+cell+viability%2C+proliferation%2C+and+arrangement+in+the+perfused+channels+comparable+to+traditional+methods.+The+model+allowed+for+the+study+of+hemodynamic+impact+on+biologically+relevant+anatomies%2C+enabling+experimental+validation+of+the+progression+of+vascular+diseases+such+as+atherosclerosis.&rft.publisher=Queensland+University+of+Technology&rft.date=2024-06-11&rft.type=Thesis&rft.format=application%2Fpdf&rft.relation=https%3A%2F%2Feprints.qut.edu.au%2F249038%2F1%2FJorge%252BAlberto%252BAmaya%252BCatano%252B-%252BThesis.pdf&rft.rights=free_to_read&rft.rights=http%3A%2F%2Fcreativecommons.org%2Flicenses%2Fby-nc-nd%2F4.0%2F&rft.relation=doi%3A10.5204%2Fthesis.eprints.249038&rft.relation=Amaya+Catano%2C+Jorge+Alberto+(2024)+A+3D+printed+hydrogel+microfluidic+vascular+model+for+studying+the+interplay+between+atherogenic+hemodynamics+and+vascular+cells.+PhD+thesis%2C+Queensland+University+of+Technology.&rft.id_number=https%3A%2F%2Feprints.qut.edu.au%2F249038%2F&rft.identifier=Faculty+of+Engineering%3B+School+of+Mechanical%2C+Medical+%26+Process+Engineering