?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=Novel+sequential+methods+in+dose-finding+designs+%3A+extensions+of+the+continual+reassessment+method&rft.creator=Darssan%2C+Darsy&rft.subject=Continual+Reassessment+Method&rft.subject=Global+cross-ratio&rft.subject=Adverse+event+relatedness&rft.subject=EM+Algorithm&rft.subject=Prior+data&rft.description=Dose-finding+trials+are+a+form+of+clinical+data+collection+process+in+which+the+primary+objective+is+to+estimate+an+optimum+dose+of+an+investigational+new+drug+when+given+to+a+patient.+This+thesis+develops+and+explores+three+novel+dose-finding+design+methodologies.+All+design+methodologies+presented+in+this+thesis+are+pragmatic.+They+use+statistical+models%2C+incorporate+clinicians'+prior+knowledge+efficiently%2C+and+prematurely+stop+a+trial+for+safety+or+futility+reasons.+Designing+actual+dose-finding+trials+using+these+methodologies+will+minimize+practical+difficulties%2C+improve+efficiency+of+dose+estimation%2C+be+flexible+to+stop+early+and+reduce+possible+patient+discomfort+or+harm.&rft.publisher=Queensland+University+of+Technology&rft.date=2014&rft.type=Thesis&rft.format=application%2Fpdf&rft.relation=https%3A%2F%2Feprints.qut.edu.au%2F69374%2F1%2FDarsy_Darssan_Thesis.pdf&rft.rights=free_to_read&rft.relation=Darssan%2C+Darsy+(2014)+Novel+sequential+methods+in+dose-finding+designs+%3A+extensions+of+the+continual+reassessment+method.+PhD+thesis%2C+Queensland+University+of+Technology.&rft.id_number=https%3A%2F%2Feprints.qut.edu.au%2F69374%2F&rft.identifier=Institute+of+Health+and+Biomedical+Innovation%3B+Science+%26+Engineering+Faculty%3B+School+of+Mathematical+Sciences