?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=Identification+and+characterization+of+novel+proteolytic+interactions+of+prostate+cancer-expressed+kallikrein-related+peptidases%2C+type+II+transmembrane+serine+proteases+and+matrix+metalloproteinases&rft.creator=Reid%2C+Janet+C.&rft.subject=Kallikrein-Related+Peptidase+(KLK)&rft.subject=Type+II+Transmembrane+Serine+Protease+(TTSP)&rft.subject=Matrix+Metalloproteinase+(MMP)&rft.subject=Protease-Activated+Receptor+(PAR)&rft.subject=Hepatocyte+Growth+Factor+Activator+Inhibitor-1&rft.subject=Hepatocyte+Growth+Factor+(HGF)&rft.subject=Calcium+Signalling&rft.subject=Activity+Based+Probe+(ABP)&rft.subject=Cell+Surface&rft.subject=Proteolytic+Cascade&rft.description=This+study+investigated+interactions+of+protein-cleaving+enzymes+(or+proteases)+that+promote+prostate+cancer+progression.+It+provides+the+first+evidence+of+a+novel+regulatory+network+of+protease+activity+at+the+surface+of+cells.+The+proteases+kallikrein-related+peptidases+4+and+14%2C+and+matrix+metalloproteinases+3+and+9+are+cleaved+at+the+cell+surface+by+the+cell+surface+proteases+hepsin+and+TMPRSS2.+These+cleavage+events+potentially+regulate+activation+of+downstream+targets+of+kallikrein+4+and+14+such+as+cell+surface+signalling+via+the+protease-activated+receptors+(PARs)+and+cell+growth-promoting+factors+such+as+hepatocyte-growth+factor.&rft.publisher=Queensland+University+of+Technology&rft.date=2015&rft.type=Thesis&rft.format=application%2Fpdf&rft.relation=https%3A%2F%2Feprints.qut.edu.au%2F81594%2F1%2FJanet_Reid_Thesis.pdf&rft.rights=free_to_read&rft.relation=Reid%2C+Janet+C.+(2015)+Identification+and+characterization+of+novel+proteolytic+interactions+of+prostate+cancer-expressed+kallikrein-related+peptidases%2C+type+II+transmembrane+serine+proteases+and+matrix+metalloproteinases.+PhD+thesis%2C+Queensland+University+of+Technology.&rft.id_number=https%3A%2F%2Feprints.qut.edu.au%2F81594%2F&rft.identifier=Faculty+of+Health%3B+Institute+of+Health+and+Biomedical+Innovation%3B+School+of+Biomedical+Sciences