title: A systematic review of hepatitis C clinical practice guidelines: Benefits, limitations and harms
creator: Lim, David
creator: Siegel, Evan
creator: Hepworth, Julie
creator: Bain, Tanya
creator: van Driel, Mieke
subject: 110309 Infectious Diseases
subject: 110316 Pathology
subject: 111706 Epidemiology
subject: 111708 Health and Community Services
subject: 111717 Primary Health Care
subject: 160508 Health Policy
subject: Hepatitis C
subject: Practice guideline
subject: Clinical management
subject: Direct acting antivirals
subject: Systematic review
description: Background    Hepatitis C (HCV) was described as a “viral time bomb”  due to its prevalence and potential for causing serious, life-threatening complications. The Australian’s National Hepatitis C Strategy calls for a coordinated, evidence-based approach to testing, management, care and support of HCV.  This review aimed to systematically and comparatively appraise existing international HCV clinical guidelines.    Methods    A systematic search of bibliographic databases and reference lists from selected papers were the source of data. Inclusion criteria were latest clinical guidelines as defined by Institute of Medicine, published in English, between January 2002 and November 2014. Quality of the guidelines was independently assessed using the iCAHE instrument.    Results    Twenty-eight international clinical practice guidelines were included. The majority of the international guidelines were based on the same primary studies however clinical recommendations on pre- and in-treatment assessments, choice of pharmaceuticals, and dosages and duration of the same pharmaceutical agents varied considerably. This diversity was beyond what would be considered reasonable practice context variations. Furthermore, there is limited guidance on post-treatment surveillance and care.    Conclusions/implications    There is a need for a harmonised international consensus on the clinical management of HCV.    Key message    A lack of consistency among international HCV clinical guidelines may impede effective and efficient patient care.
contributor: Yeatman, Heather
contributor: Clarke, Kerri
contributor: Crawford, Gemma
contributor: Gleeson, Suzanne
contributor: Holt, Dominique
contributor: Lamontagne, Anthony
date: 2015-09
type: Conference Item
format: application/vnd.openxmlformats-officedocument.presentationml.presentation
relation: https://eprints.qut.edu.au/87520/3/sys%20rv%20of%20clinical%20practice%20guideline%2020150913.pptx
relation: DOI:10.13140/RG.2.1.2701.1042
relation:    Lim, David, Siegel, Evan, Hepworth, Julie, Bain, Tanya,  & van Driel, Mieke   (2015)   A systematic review of hepatitis C clinical practice guidelines: Benefits, limitations and harms. In  Yeatman, Heather, Clarke, Kerri, Crawford, Gemma, Gleeson, Suzanne, Holt, Dominique,  & Lamontagne, Anthony (Eds.)  Population Health Congress 2015, 6-9 September 2015, Hobart, Tasmania. (Unpublished)   
identifier: https://eprints.qut.edu.au/87520/
rights: Copyright 2015 [please consult the authors]
source: Faculty of Health; Institute of Health and Biomedical Innovation