?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=Determination+of+the+effect+of+JO146%2C+a+CtHtrA+inhibitor%2C+on+the+chlamydial+developmental+cycle+and+persistence&rft.creator=Ong%2C+Vanissa+A.&rft.subject=Chlamydia+trachomatis&rft.subject=intracellular+pathogen&rft.subject=clinical+isolate&rft.subject=HtrA&rft.subject=protease&rft.subject=inhibitor&rft.subject=mutants&rft.subject=developmental+cycle&rft.description=The+role+of+Chlamydia+trachomatis+HtrA+(CtHtrA)+for+the+growth+and+pathogenesis+of+this+organism+is+presented.+Inhibition+of+CtHtrA+led+to+loss+of+infectious+progeny+in+Chlamydia%2C+particularly+during+heat+stress+or+recovery+from+penicillin+persistence.+Isolation+of+CtHtrA+inhibitor+resistant+mutants+identified+positive+selection+for+mutants+in+fatty+acid+related+pathways.+Importantly%2C+HtrA+inhibition+was+effective+against+clinical+isolates+of+C.+trachomatis.+Thus+the+findings+combined+indicate+that+CtHtrA+is+an+important+chlamydial+growth+factor+that+has+the+potential+to+be+targeted+for+the+development+of+anti-chlamydial+drugs+in+the+future.&rft.publisher=Queensland+University+of+Technology&rft.date=2015&rft.type=Thesis&rft.format=application%2Fpdf&rft.relation=https%3A%2F%2Feprints.qut.edu.au%2F89931%2F1%2FVanissa_Ong_Thesis.pdf&rft.rights=free_to_read&rft.relation=Ong%2C+Vanissa+A.+(2015)+Determination+of+the+effect+of+JO146%2C+a+CtHtrA+inhibitor%2C+on+the+chlamydial+developmental+cycle+and+persistence.+PhD+thesis%2C+Queensland+University+of+Technology.&rft.id_number=https%3A%2F%2Feprints.qut.edu.au%2F89931%2F&rft.identifier=Faculty+of+Health%3B+Institute+of+Health+and+Biomedical+Innovation%3B+School+of+Biomedical+Sciences