?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=Novel+dual-acting+nitroxide-based+hybrid+antioxidants&rft.creator=Thomas%2C+Komba&rft.subject=Nitroxides&rft.subject=Antioxidant&rft.subject=Catechols&rft.subject=Oxidative+Stress&rft.subject=Chronic+Inflammation&rft.subject=Paramagnetic+Broadening&rft.subject=Site+Directed+Spin+Label%2C+Synthesis&rft.subject=Sch%C3%B6llkopf&rft.subject=Nonsteroidal+Anti-inflammatory+Drugs&rft.subject=Pharmacophore+Hybridization&rft.description=This+project+employed+a+rational+drug+design+and+development+approached+to+make+hybrid+dual-acting+antioxidants+as+potential+medications+for+managing+chronic+inflammation+and+oxidative+stress-related+diseases+such+as+arthritis+and+Parkinson+disease.+The+approach+(pharmacophore+hybridization+strategy)+combined+various+nitroxide+compounds+with+known+drugs+-+mainly+the+NSAID+and+sympathomimetic+stimulants+class+of+drugs.+The+hybrid+compounds+developed+in+this+project+displayed+promising+therapeutic+actions+as+antioxidant%2C+anti-inflammatory+and+anticancer+agents.&rft.publisher=Queensland+University+of+Technology&rft.date=2016&rft.type=Thesis&rft.format=application%2Fpdf&rft.relation=https%3A%2F%2Feprints.qut.edu.au%2F97691%2F9%2FKomba_Thomas_Thesis.pdf&rft.rights=free_to_read&rft.relation=Thomas%2C+Komba+(2016)+Novel+dual-acting+nitroxide-based+hybrid+antioxidants.+PhD+thesis%2C+Queensland+University+of+Technology.&rft.id_number=https%3A%2F%2Feprints.qut.edu.au%2F97691%2F&rft.identifier=Science+%26+Engineering+Faculty%3B+School+of+Chemistry%2C+Physics+%26+Mechanical+Engineering