Investigation the possibility of using peptides with a helical repeating pattern of hydro-phobic and hydrophilic residues to inhibit IL-10

Ni, Guoying, Chen, Shu, Yang, Yuedong, Cummins, Scott, Zhan, Jian, Li, Zhixiu, Zhu, Bin, Mounsey, Kate, Walton, Shelley, Wei, Ming, Wang, Yuejian, Zhou, Yaoqi, Wang, Tianfang, & Liu, Xiaosong (2016) Investigation the possibility of using peptides with a helical repeating pattern of hydro-phobic and hydrophilic residues to inhibit IL-10. PLoS One, 11(4), Article number: e0153939 1-19.

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Description

Blockade of IL-10 signalling clears chronic viral and bacterial infections. Immunization together with blockade of IL-10 signalling or relatively low level of IL-10 further enhances viral and bacterial clearance. IL-10 functions through binding to interleukin 10 receptor (IL-10R). Here we showed that peptides P1 and P2 with the hydrophobic and hydrophilic pattern of the IL10R-binding helix in IL-10 could bind with either IL-10R1 or IL-10, and inhibit inflammatory signals with long duration and negligible cytotoxicity in vitro. Furthermore, P2 can enhance antigen specific CD8+ T cell responses in mice induced by the vaccine based on a long peptide of protein E7 in a human papillomavirus type 16.

Impact and interest:

13 citations in Scopus

11 citations in Web of Science®

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ID Code:

108216

Item Type:

Contribution to Journal (Journal Article)

Refereed:

Yes

ORCID iD:

Li, Zhixiu	orcid.org/0000-0002-2924-9120

Measurements or Duration:

19 pages

Keywords:

Interleukin 10 (IL-10), chronic viral and bacterial infections, helical repeating pattern, hydro-phobic, peptides

DOI:

10.1371/journal.pone.0153939

ISSN:

1932-6203

Pure ID:

33113960

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Deposited On:

26 Jun 2017 01:24

Last Modified:

01 Mar 2024 17:29

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