Genome-wide association study in Guillain-Barre syndrome
Blum, Stefan, Ji, Ying, Pennisi, David, Li, Zhixiu, Leo, Paul, McCombe, Pamela, & Brown, Matt (2018) Genome-wide association study in Guillain-Barre syndrome. Journal of Neuroimmunology, 323, pp. 109-114.
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Description
Guillain-Barre syndrome (GBS) is considered to have an immune-mediated basis, but the genetic contribution to GBS is unclear. We conducted a GWAS involving 215 GBS patients and 1,105 healthy controls. No significant associations of individual SNPs or imputed HLA types were observed. We performed a genome-wide complex trait analysis for evaluation of the heritability of GBS, and found that common SNPs contribute up to 25% of susceptibility to the disease. Genetic risk score analysis showed no evidence of overlap in genetic susceptibility factors of GBS and multiple sclerosis. Given the unexplained heritability of the trait further larger GWAS are indicated.
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| ID Code: | 124009 | ||||||
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| Item Type: | Contribution to Journal (Journal Article) | ||||||
| Refereed: | Yes | ||||||
| ORCID iD: |
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| Measurements or Duration: | 6 pages | ||||||
| Keywords: | Case-control study, Genetic risk score, Genome-wide association study, Guillain-Barre syndrome, Heritability, Human leukocyte antigen (HLA) genes | ||||||
| DOI: | 10.1016/j.jneuroim.2018.07.016 | ||||||
| ISSN: | 0165-5728 | ||||||
| Pure ID: | 33384653 | ||||||
| Divisions: | Past > QUT Faculties & Divisions > Faculty of Health Past > Institutes > Institute of Health and Biomedical Innovation |
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| Funding: | |||||||
| Copyright Owner: | Consult author(s) regarding copyright matters | ||||||
| Copyright Statement: | This work is covered by copyright. Unless the document is being made available under a Creative Commons Licence, you must assume that re-use is limited to personal use and that permission from the copyright owner must be obtained for all other uses. If the document is available under a Creative Commons License (or other specified license) then refer to the Licence for details of permitted re-use. It is a condition of access that users recognise and abide by the legal requirements associated with these rights. If you believe that this work infringes copyright please provide details by email to qut.copyright@qut.edu.au | ||||||
| Deposited On: | 07 Jan 2019 13:33 | ||||||
| Last Modified: | 13 Nov 2025 03:43 |
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