Mathematical modelling of ultrasensitivity in enzyme-mediated reactions
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Cailan Jeynes Smith Thesis
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Description
This thesis presents a thorough mathematical investigation of the important phenomenon of Ultrasensitivity in enzyme-mediated chemical reaction networks. The study considers several novel chemical reaction networks, and develops a robust new nomenclature that allows Ultrasensitivity to be analysed in precise quantitative terms. This investigation encompasses both stochastic and deterministic simulations, as well as analytical methods, which together provide a comprehensive understanding of ultrasensitivity-promoting mechanisms in simple chemical reaction networks.
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| ID Code: | 174502 |
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| Item Type: | QUT Thesis (Master of Philosophy) |
| Supervisor: | Araujo, Robyn & Burrage, Pamela |
| Keywords: | mathematical modelling, enzyme-kinetics, ultrasensitivity, chemical reaction networks, covalent-modification, network motifs, dynamical systems, stochastic simulation |
| DOI: | 10.5204/thesis.eprints.174502 |
| Divisions: | Past > QUT Faculties & Divisions > Science & Engineering Faculty Current > Schools > School of Mathematical Sciences |
| Institution: | Queensland University of Technology |
| Deposited On: | 25 Mar 2020 05:16 |
| Last Modified: | 25 Mar 2020 05:16 |
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