Cell death and thymic tolerance
Description
The differentiation of hematopoietic precursors into the many functionally distinct T‐cell types produced by the thymus is a complex process. It proceeds through a series of stages orchestrated by a variety of thymic microenvironments that shape the T‐cell developmental processes. Numerous cytokine and cell surface receptors direct thymocyte differentiation but the primary determinant of cell fate is the engagement of the T‐cell antigen receptor (TCR ). The strength of the TCR signal and the maturation stage of the thymocyte receiving it can direct the various differentiation programs or, alternatively, end the process by inducing cell death. The regulation of thymocyte death is critical for the efficiency of thymic T‐cell differentiation and the preservation of immune tolerance. A detailed knowledge of mechanisms that eliminate thymocytes from the T‐cell repertoire is essential to understand the “logic” of T‐cell selection in the thymus. This review focuses on the central role of the BCL ‐2 family of proteins in the apoptotic checkpoints that punctuate thymocyte differentiation and the consequences of defects in these processes.
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ID Code: | 202391 | ||
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Item Type: | Contribution to Journal (Journal Article) | ||
Refereed: | Yes | ||
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Additional Information: | Special Issue: Molecular Mechanisms of Cell Death | ||
Measurements or Duration: | 12 pages | ||
DOI: | 10.1111/imr.12532 | ||
ISSN: | 0105-2896 | ||
Pure ID: | 63565326 | ||
Copyright Owner: | John Wiley and Sons A/S | ||
Copyright Statement: | This work is covered by copyright. Unless the document is being made available under a Creative Commons Licence, you must assume that re-use is limited to personal use and that permission from the copyright owner must be obtained for all other uses. If the document is available under a Creative Commons License (or other specified license) then refer to the Licence for details of permitted re-use. It is a condition of access that users recognise and abide by the legal requirements associated with these rights. If you believe that this work infringes copyright please provide details by email to qut.copyright@qut.edu.au | ||
Deposited On: | 22 Jul 2020 05:36 | ||
Last Modified: | 16 Jun 2024 19:08 |
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