Browse By Person: Daley, Stephen

Jauch, Annaïse J., Bignucolo, Olivier, Seki, Sayuri, Ghraichy, Marie, Delmonte, Ottavia M., von Niederhauser, Valentin, Higgins, Rebecca, Ghosh, Adhideb, Nishizawa, Masako, Tanaka, Mariko, Baldrich, Adrian, Koppen, Julius, Hirsiger, Julia R., Hupfer, Robin, Ehl, Stephan, Rensing-Ehl, Anne, Hopfer, Helmut, Prince, Spasenija Savic, Daley, Stephen R., Marquardsen, Florian A., Meyer, Benedikt J., Tamm, Michael, Daikeler, Thomas D., Diesch, Tamara, Kühne, Thomas, Helbling, Arthur, Berkemeier, Caroline, Heijnen, Ingmar, Navarini, Alexander A., Trück, Johannes, de Villartay, Jean Pierre, Oxenius, Annette, Berger, Christoph T., Hess, Christoph, Notarangelo, Luigi D., Yamamoto, Hiroyuki, & Recher, Mike (2023) Autoimmunity and immunodeficiency associated with monoallelic LIG4 mutations via haploinsufficiency. Journal of Allergy and Clinical Immunology, 152(2), pp. 500-516.

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Szeto, Christopher, Zareie, Pirooz, Wirasinha, Rushika C., Zhang, Justin B., Nguyen, Andrea T., Riboldi-Tunnicliffe, Alan, La Gruta, Nicole L., Gras, Stephanie, & Daley, Stephen R. (2022) Covalent TCR-peptide-MHC interactions induce T cell activation and redirect T cell fate in the thymus. Nature Communications, 13, Article number: 4951.

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Nussing, Simone, Miosge, Lisa A., Lee, Kah, Olshansky, Moshe, Barugahare, Adele, Roots, Carla M., Sontani, Yovina, Day, E. Bridie, Koutsakos, Marios, Kedzierska, Katherine, Goodnow, Christopher C., Russ, Brendan E., Daley, Stephen R., & Turner, Stephen J. (2022) SATB1 ensures appropriate transcriptional programs within naive CD8+ T cells. Immunology and Cell Biology, 100(8), pp. 636-652.

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Wang, Chenglong & Daley, Stephen R. (2022) How Thymocyte Deletion in the Cortex May Curtail Antigen-Specific T-Regulatory Cell Development in the Medulla. Frontiers in Immunology, 13, Article number: 892498.

Delmonte, Ottavia M., Castagnoli, Riccardo, Yu, Jason, Dvorak, Christopher C., Cowan, Morton J., Davila Saldana, Blachy J., De Ravin, Suk See, Mamcarz, Ewelina, Chang, Catherine K, Daley, Stephen R, Griffith, Linda M., Notarangelo, Luigi D., & Puck, Jennifer M. (2022) Poor T-cell receptor beta Repertoire Diversity Early Post-transplant for Severe Combined Immunodeficiency Predicts Failure of Immune Reconstitution. Journal of Allergy and Clinical Immunology, 149(3), pp. 1113-1119.

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Delmonte, Ottavia M, Bergerson, Jenna Ruth Ember, Kawai, Tomoki, Kuehn, Hye Sun, McDermott, David H, Cortese, Irene, Zimmermann, Michael T, Dobbs, Kerry, Bosticardo, Marita, Fink, Danielle, Majumdar, Shamik, Palterer, Boaz, Pala, Francesca, Dsouza, Nikita R, Pouzolles, Marie, Taylor, Naomi, Calvo, Katherine Rainsford, Daley, Stephen R, Velez, Daniel S, Agharahimi, Anahita, Myint-Hpu, Katherine, Dropulic, Lesia, Lyons, Jonathan J, Holland, Steven M, Freeman, Alexandra F, Ghosh, Rajarshi, Similuk, Morgan N, Niemela, Julie E, Stoddard, Jennifer L, Kuhns, Douglas B, Urrutia, Raul, Rosenzweig, Sergio, Walkiewicz, Magdalena A, Murphy, Philip, & Notarangelo, Luigi D (2021) SASH3 variants cause a novel form of X-linked combined immunodeficiency with immune dysregulation. Blood, 138(12), pp. 1019-1033.

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Fulford, Thomas S., Grumont, Raelene, Wirasinha, Rushika C., Ellis, Darcy, Barugahare, Adele, Turner, Stephen J., Naeem, Haroon, Powell, David, Lyons, Paul A., Smith, Kenneth G.C., Scheer, Sebastian, Zaph, Colby, Klein, Ulf, Daley, Stephen R., & Gerondakis, Steve (2021) c-Rel employs multiple mechanisms to promote the thymic development and peripheral function of regulatory T cells in mice. European Journal of Immunology, 51(8), pp. 2006-2026.

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Barthlott, Thomas, Handel, Adam E., Teh, Hong Ying, Wirasinha, Rushika C., Hafen, Katrin, Zuklys, Saulius, Roch, Benoit, Orkin, Stuart H., de Villartay, Jean Pierre, Daley, Stephen R., & Hollander, Georg A. (2021) Indispensable epigenetic control of thymic epithelial cell development and function by polycomb repressive complex 2. Nature Communications, 12(1), Article number: 3933.

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Wirasinha, Rushika C., Davies, Ainsley R., Srivastava, Monika, Sheridan, Julie M., Sng, Xavier Y.X., Delmonte, Ottavia M., Dobbs, Kerry, Loh, Khai L., Miosge, Lisa A., Lee, Cindy Eunhee, Chand, Rochna, Chan, Anna, Yap, Jin Yan, Keller, Michael D., Chen, Karin, Rossjohn, Jamie, la Gruta, Nicole L., Vinuesa, Carola G., Reid, Hugh H., Lionakis, Michail S., Notarangelo, Luigi D., Gray, Daniel H.D., Goodnow, Christopher C., Cook, Matthew C., & Daley, Stephen R. (2021) Nfkb2 variants reveal a p100-degradation threshold that defines autoimmune susceptibility. Journal of Experimental Medicine, 218(2), Article number: e20200476 1-19.

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Randall, Katrina L., Law, Hsei Di, Ziolkowski, Andrew F., Wirasinha, Rushika C., Goodnow, Christopher C., & Daley, Stephen R. (2021) DOCK8 deficiency diminishes thymic T-regulatory cell development but not thymic deletion. Clinical and Translational Immunology, 10(1), Article number: e1236.

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Sng, Xavier Y.X., Li, Jasmine, Zareie, Pirooz, Assmus, Lisa M., Lee, Jason K.C., Jones, Claerwen M., Turner, Stephen J., Daley, Stephen R., Quinn, Kylie M., & la Gruta, Nicole L. (2020) The impact of MHC class I dose on development and maintenance of the polyclonal naive CD8+ T cell repertoire. Journal of Immunology, 204(12), pp. 3108-3116.

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Wirasinha, Rushika C., Chan, Anna, Yap, Jin Yan, Hu, Daniel Y., Teh, Charis E., Gray, Daniel H.D., Goodnow, Christopher C., & Daley, Stephen R. (2019) Deletion of self-reactive CCR7-thymocytes in the absence of MHC expression on thymic epithelial cells. Cell Death and Differentiation, 26(12), pp. 2727-2739.

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Zammit, Nathan W., Siggs, Owen M., Gray, Paul E., Horikawa, Keisuke, Langley, David B., Walters, Stacey N., Daley, Stephen R., Loetsch, Claudia, Warren, Joanna, Yap, Jin Yan, Cultrone, Daniele, Russell, Amanda, Malle, Elisabeth K., Villanueva, Jeanette E., Cowley, Mark J., Gayevskiy, Velimir, Dinger, Marcel E., Brink, Robert, Zahra, David, Chaudhri, Geeta, Karupiah, Gunasegaran, Whittle, Belinda, Roots, Carla, Bertram, Edward, Yamada, Michiko, Jeelall, Yogesh, Enders, Anselm, Clifton, Benjamin E., Mabbitt, Peter D., Jackson, Colin J., Watson, Susan R., Jenne, Craig N., Lanier, Lewis L., Wiltshire, Tim, Spitzer, Matthew H., Nolan, Garry P., Schmitz, Frank, Aderem, Alan, Porebski, Benjamin T., Buckle, Ashley M., Abbott, Derek W., Ziegler, John B., Craig, Maria E., Benitez-Aguirre, Paul, Teo, Juliana, Tangye, Stuart G., King, Cecile, Wong, Melanie, Cox, Murray P., Phung, Wilson, Tang, Jia, Sandoval, Wendy, Wertz, Ingrid E., Christ, Daniel, Goodnow, Christopher C., & Grey, Shane T. (2019) Denisovan, modern human and mouse TNFAIP3 alleles tune A20 phosphorylation and immunity. Nature Immunology, 20(10), pp. 1299-1310.

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Daley, Stephen R., Koay, Hui Fern, Dobbs, Kerry, Bosticardo, Marita, Wirasinha, Rushika C., Pala, Francesca, Castagnoli, Riccardo, Rowe, Jared H., Ott de Bruin, Lisa M., Keles, Sevgi, Lee, Yu Nee, Somech, Raz, Holland, Steven M., Delmonte, Ottavia M., Draper, Debbie, Maxwell, Sandra, Niemela, Julie, Stoddard, Jennifer, Rosenzweig, Sergio D., Poliani, Pietro Luigi, Capo, Valentina, Villa, Anna, Godfrey, Dale I., & Notarangelo, Luigi D. (2019) Cysteine and hydrophobic residues in CDR3 serve as distinct T-cell self-reactivity indices. Journal of Allergy and Clinical Immunology, 144(1), pp. 333-336.

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Koay, H. F., Su, S., Amann-Zalcenstein, D., Daley, S. R., Comerford, I., Miosge, L., Whyte, C. E., Konstantinov, I. E., D'Udekem, Y., Baldwin, T., Hickey, P. F., Berzins, S. P., Mak, J. Y.W., Sontani, Y., Roots, C. M., Sidwell, T., Kallies, A., Chen, Z., Nussing, S., Kedzierska, K., Mackay, L. K., McColl, S. R., Deenick, E. K., Fairlie, D. P., McCluskey, J., Goodnow, C. C., Ritchie, M. E., Belz, G. T., Naik, S. H., Pellicci, D. G., & Godfrey, D. I. (2019) A divergent transcriptional landscape underpins the development and functional branching of MAIT cells. Science Immunology, 4(41), Article number: eaay6039.

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Yap, J.Y., Wirasinha, R.C., Chan, Anna, Howard, Debbie R., Goodnow, Christopher C., & Daley, Stephen R. (2018) Indirect presentation in the thymus limits naive and regulatory T-cell differentiation by promoting deletion of self‐reactive thymocytes. Immunology, 154(3), pp. 522-532.

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Wirasinha, R.C., Singh, Mandeep, Archer, Stuart K., Chan, Anna, Harrison, Paul F., Goodnow, C.C., & Daley, S.R. (2018) [ab] T‐cell receptors with a central CDR 3 cysteine are enriched in CD [8aa] intraepithelial lymphocytes and their thymic precursors. Immunology and Cell Biology, 96(6), pp. 553-561.

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la Gruta, Nicole L., Gras, Stephanie, Daley, S.R., Thomas, Paul G., & Rossjohn, Jamie (2018) Understanding the drivers of MHC restriction of T cell receptors. Nature Reviews Immunology, 18, pp. 467-478.

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Hu, Daniel Y., Wirasinha, Rushika C, Goodnow, Christopher C., & Daley, Stephen (2017) IL-2 prevents deletion of developing T-regulatory cells in the thymus. Cell Death and Differentiation, 24(6), 1007–1016.

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Daley, S.R., Teh, Charis, Hu, Daniel Y., Strasser, Andreas, & Gray, Daniel H.D. (2017) Cell death and thymic tolerance. Immunological Reviews, 277(1), pp. 9-20.

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Voigt, Valentina, Wikstrom, Matthew E., Kezic, Jelena M., Schuster, Iona S., Fleming, Peter, Makinen, Kimmo, Daley, Stephen R., Andoniou, Christopher E., Degli-Esposti, Mariapia A., & Forrester, John V. (2017) Ocular antigen does not cause disease unless presented in the context of inflammation. Scientific Reports, 7, Article number: 14226.

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Hu, Daniel Y., Yap, Jin Y., Wirasinha, R.C., Howard, Debbie R., Goodnow, C.C., & Daley, S.R. (2016) A timeline demarcating two waves of clonal deletion and Foxp3 upregulation during thymocyte development. Immunology and Cell Biology, 94(4), pp. 357-366.

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Daley, S.R. (2015) Prolonged access to thymic epithelial MHCI seals CD8+ lineage commitment. Immunology and Cell Biology, 93(4), pp. 326-327.

Siggs, O.M., Miosge, Lisa A., Daley, S.R., Asquith, K., Foster, Paul S., Liston, Adrian, & Goodnow, C.C. (2015) Quantitative reduction of the TCR adapter protein SLP-76 unbalances immunity and immune regulation. Journal of Immunology, 194(6), pp. 2587-2595.

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Walters, Stacey N., Webster, Kylie E., Daley, S., & Grey, Shane T. (2014) A role for intrathymic B cells in the generation of natural regulatory T cells. Journal of Immunology, 193(1), pp. 170-176.

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Altin, John A., Daley, Stephen R., Howitt, Jason, Rickards, Helen J., Batkin, Alison K., Horikawa, Keisuke, Prasad, Simon J., Nelms, Keats A., Kumar, Sharad, Wu, Lawren C., Tan, Seong-Seng, Cook, Matthew C., & Goodnow, Christopher C. (2014) Ndfip1 mediates peripheral tolerance to self and exogenous antigen by inducing cell cycle exit in responding CD4+ T cells. Proceedings of the National Academy of Sciences of the United States of America, 111(6), 2067–2074.

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Daley, Stephen R., Coakley, Kristen M., Hu, Daniel Y., Randall, Katrina L., Jenne, Craig N., Limnander, Andre, Myers, Darienne R., Polakos, Noelle K., Enders, Anselm, Roots, Carla, Balakishnan, Bhavani, Miosge, Lisa A., Sjollema, Geoff, Bertram, Edward M., Field, Matthew A., Shao, Yunli, Andrews, T. Daniel, Whittle, Belinda, Barnes, S Whitney, Walker, John R., Cyster, Jason G., Goodnow, Christopher, & Roose, Jeroen P. (2013) Rasgrp1 mutation increases naïve T-cell CD44 expression and drives mTOR-dependent accumulation of Helios+ T cells and autoantibodies. eLife, 2, Article number: e01020.

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Daley, S.R., Hu, Daniel Y., & Goodnow, Christopher C. (2013) Helios marks strongly autoreactive CD4+ T cells in two major waves of thymic deletion distinguished by induction of PD-1 or NF-κB. Journal of Experimental Medicine, 210(2), 269–285.

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Chen, Guobing, Hardy, Kristine, Pagler, Eloisa, Ma, Lina, Lee, Seungsoo, Gerondakis, Steve, Daley, Stephen, & Shannon, M. Frances (2011) The NF-κB transcription factor c-Rel is required for Th17 effector cell development in experimental autoimmune encephalomyelitis. Journal of Immunology, 187(9), pp. 4483-4491.

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Silva, Diego, Daley, Stephen, Hogan, Jennifer, Lee, Candice, Teh, Charis, Hu, Daniel, Lam, Kong-Peng, Goodnow, Christopher, & Vinuesa, Carola (2011) Anti-islet autoantibodies trigger autoimmune diabetes in the presence of an increased frequency of islet-reactive CD4 T cells. Diabetes, 60(8), pp. 2102-2111.

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Teh, Charis E., Daley, Stephen R., Enders, Anselm, & Goodnow, Christopher C. (2010) T-cell regulation by casitas B-lineage lymphoma (Cblb) is a critical failsafe against autoimmune disease due to autoimmune regulator (Aire) deficiency. Proceedings of the National Academy of Sciences of the United States of America, 107(33), pp. 14709-14714.

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Chen, Guobing, Hardy, Kristine, Bunting, Karen, Daley, S., Ma, Lina, & Shannon, M. Frances (2010) Regulation of the IL-21 gene by the NF-κB transcription factor c-Rel. Journal of Immunology, 185(4), pp. 2350-2359.

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Howie, D., Nolan, K.F., Daley, S., Butterfield, E., Adams, E., Garcia-Rueda, H., Thompson, C., Saunders, N.J., Cobbold, S.P., Tone, Y., Tone, M., & Waldmann, H. (2009) MS4A4B is a GITR-associated membrane adapter, expressed by regulatory T cells, which modulates T cell activation. Journal of Immunology, 183(7), pp. 4197-4204.

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Daley, S.R., Cobbold, S.P., & Waldmann, H. (2008) Fc-disabled anti-mouse CD40l antibodies retain efficacy in promoting transplantation tolerance. American Journal of Transplantation, 8(11), pp. 2265-2271.

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Daley, S.R., Ma, J., Adams, E., Cobbold, S.P., & Waldmann, H. (2007) A key role for TGF-β signaling to T cells in the long-term acceptance of allografts. Journal of Immunology, 179(6), pp. 3648-3654.

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Graca, L., Daley, S., Fairchild, P.J., Cobbold, S.P., & Waldmann, H. (2006) Co-receptor and co-stimulation blockade for mixed chimerism and tolerance without myelosuppressive conditioning. BMC Immunology, 7, Article number: 9.

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Cobbold, S.P., Adams, E., Graca, L., Daley, S., Yates, S., Paterson, A., Robertson, N.J., Nolan, K.F., Fairchild, P.J., & Waldmann, H. (2006) Immune privilege induced by regulatory T cells in transplantation tolerance. Immunological Reviews, 213(1), pp. 239-255.

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Waldmann, H., Chen, T.-C., Graca, L., Adams, E., Daley, S., Cobbold, S., & Fairchild, P.J. (2006) Regulatory T cells in transplantation. Seminars in Immunology, 18(2), pp. 111-119.

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