Controlled release vaccine implants for delivery of booster immunisations
Description
Most current animal vaccine regimes involve a primary vaccination followed sometime later by a booster vaccination. This presents challenges when vaccinating difficult to access animals such as livestock. Mustering livestock to deliver a vaccine boost is costly and stressful for animals. Thus, we have produced a platform system that can be administered at the same time as the priming immunisation and delivers payload after an appropriate delay time to boost the immune response, without need for further handling of animals. A 30 × 2 mm osmotically triggered polymer implant device with burst-release characteristics delivered the booster dose of a tetanus vaccine. Blood samples were collected from an experimental group that received the priming vaccine and implant on day 0 and control group that received the initial vaccine (tetanus toxoid) and then a bolus dose 28 days later via subcutaneous injection. The two groups showed identical weight gain curves. T cell proliferation following in vitro stimulation with antigen was identical between the two groups at all time points. However, serum IgG antibody responses to the tetanus toxoid antigen were significantly higher in the control group at weeks 8 and 12. The implant capsules stayed at the site of implantation and at week 12 there was evidence of tissue integration. No local reactions at the implant site were observed, other than mild thickening of the skin in half of the experimental group animals and no other adverse health events were recorded in either group.
Impact and interest:
Citation counts are sourced monthly from Scopus and Web of Science® citation databases.
These databases contain citations from different subsets of available publications and different time periods and thus the citation count from each is usually different. Some works are not in either database and no count is displayed. Scopus includes citations from articles published in 1996 onwards, and Web of Science® generally from 1980 onwards.
Citations counts from the Google Scholar™ indexing service can be viewed at the linked Google Scholar™ search.
ID Code: | 235555 | ||||||||
---|---|---|---|---|---|---|---|---|---|
Item Type: | Contribution to Journal (Journal Article) | ||||||||
Refereed: | Yes | ||||||||
ORCID iD: |
|
||||||||
Additional Information: | Funding Information: This work was supported by the Division of Business Development , QUT. | ||||||||
Measurements or Duration: | 9 pages | ||||||||
Keywords: | Biodegradable, Delayed release, Livestock, Poly(ε-caprolactone), Vaccine delivery | ||||||||
DOI: | 10.1016/j.vetimm.2022.110484 | ||||||||
ISSN: | 0165-2427 | ||||||||
Pure ID: | 116264871 | ||||||||
Divisions: | Current > Research Centres > Centre for Behavioural Economics, Society & Technology Current > Research Centres > Centre for Materials Science ?? 1479430 ?? Current > Research Centres > Centre for Immunology and Infection Control Current > QUT Faculties and Divisions > Academic Division Current > QUT Faculties and Divisions > Faculty of Business & Law Current > QUT Faculties and Divisions > Faculty of Science Current > Schools > School of Chemistry & Physics Current > QUT Faculties and Divisions > Faculty of Engineering Current > Schools > School of Mechanical, Medical & Process Engineering Current > QUT Faculties and Divisions > Faculty of Health Current > Schools > School of Biomedical Sciences |
||||||||
Funding Information: | This work was supported by the Division of Business Development , QUT. | ||||||||
Copyright Owner: | 2022 Elsevier B.V. | ||||||||
Copyright Statement: | This work is covered by copyright. Unless the document is being made available under a Creative Commons Licence, you must assume that re-use is limited to personal use and that permission from the copyright owner must be obtained for all other uses. If the document is available under a Creative Commons License (or other specified license) then refer to the Licence for details of permitted re-use. It is a condition of access that users recognise and abide by the legal requirements associated with these rights. If you believe that this work infringes copyright please provide details by email to qut.copyright@qut.edu.au | ||||||||
Deposited On: | 12 Oct 2022 01:36 | ||||||||
Last Modified: | 01 Jul 2024 11:12 |
Export: EndNote | Dublin Core | BibTeX
Repository Staff Only: item control page