Broth recycling to reduce process noise resulting from concentrated substrate addition in fed-batch cultivation of Escherichia coli
Description
In this work feed hardware for fed-batch cultivation is presented (broth recycle feed injection system or BRFIS). BRFIS proved superior to conventional submerged or dripped feed systems in reducing dissolved oxygen (DO) oscillations during Escherichia coli fed-batch cultivation (5 min coefficient of variation of 0.7% for BRFIS as compared to 26% or greater for conventional feeding hardware in a 2 L test reactor). Hence, BRFIS is useful for fed-batch cultivation systems where the DO signal is used in measurement or control.
Impact and interest:
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| ID Code: | 241620 | ||
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| Item Type: | Contribution to Journal (Journal Article) | ||
| Refereed: | Yes | ||
| ORCID iD: |
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| Measurements or Duration: | 3 pages | ||
| DOI: | 10.1021/bp025659i | ||
| ISSN: | 8756-7938 | ||
| Pure ID: | 139970889 | ||
| Copyright Owner: | 2003 American Institute of Chemical Engineers (AIChE) | ||
| Copyright Statement: | This work is covered by copyright. Unless the document is being made available under a Creative Commons Licence, you must assume that re-use is limited to personal use and that permission from the copyright owner must be obtained for all other uses. If the document is available under a Creative Commons License (or other specified license) then refer to the Licence for details of permitted re-use. It is a condition of access that users recognise and abide by the legal requirements associated with these rights. If you believe that this work infringes copyright please provide details by email to qut.copyright@qut.edu.au | ||
| Deposited On: | 18 Jul 2023 04:22 | ||
| Last Modified: | 03 Mar 2024 19:32 |
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