DNA labelling in live cells via visible light-induced [2+2] photocycloaddition
Michenfelder, Rita T., Delafresnaye, Laura, Truong, Vinh X., Barner-Kowollik, Christopher, & Wagenknecht, Hans Achim (2023) DNA labelling in live cells via visible light-induced [2+2] photocycloaddition. Chemical Communications, 59(27), pp. 4012-4015.
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Description
We introduce a visible light-driven (λmax = 451 nm) photo-chemical strategy for labelling of DNA in living HeLa cells via the [2+2] cycloaddition of a styrylquinoxaline moiety, which we incorporate into both the DNA and the fluorescent label. Our methodology offers advanced opportunities for the mild remote labelling of DNA in water while avoiding UV light activation.
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| ID Code: | 243244 | ||||
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| Item Type: | Contribution to Journal (Journal Article) | ||||
| Refereed: | Yes | ||||
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| Additional Information: | We thank M. Sc. Maren Schrödter for carrying out PAGE analysis of DNA5. C. B.-K. acknowledges funding from the Australian Research Council (ARC) via a Laureate Fellowship as well as continued funding from QUT's Centre for Materials Science. R.T.M. acknowledges a PhD scholarship (KIT). H.-A. W. thanks the Deutsche Forschungsgemeinschaft (DFG) for support (Wa 1386/22-1 and GRK 2039/2). | ||||
| Measurements or Duration: | 4 pages | ||||
| DOI: | 10.1039/d3cc00817g | ||||
| ISSN: | 1359-7345 | ||||
| Pure ID: | 146250363 | ||||
| Divisions: | Current > Research Centres > Centre for Materials Science Current > QUT Faculties and Divisions > Academic Division Current > QUT Faculties and Divisions > Faculty of Science Current > Schools > School of Chemistry & Physics |
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| Copyright Owner: | 2023 The Royal Society of Chemistry. | ||||
| Copyright Statement: | This work is covered by copyright. Unless the document is being made available under a Creative Commons Licence, you must assume that re-use is limited to personal use and that permission from the copyright owner must be obtained for all other uses. If the document is available under a Creative Commons License (or other specified license) then refer to the Licence for details of permitted re-use. It is a condition of access that users recognise and abide by the legal requirements associated with these rights. If you believe that this work infringes copyright please provide details by email to qut.copyright@qut.edu.au | ||||
| Deposited On: | 03 Oct 2023 15:00 | ||||
| Last Modified: | 02 Feb 2026 21:48 |
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