A 3D printed hydrogel microfluidic vascular model for studying the interplay between atherogenic hemodynamics and vascular cells
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Jorge Alberto Amaya Catano Thesis. Available under License Creative Commons Attribution Non-commercial No Derivatives 4.0. |
Description
This work presents a new approach for patient-specific vascular models, capturing anatomy, hemodynamic, and cell arrangement. MRI images were utilized to create 3D models of carotid vessel bifurcations. Computational fluid dynamics was employed to investigate hemodynamics. Replicas of the carotid vessel were produced via 3D-DLP bioprinting, resembling cellular organization with embedded human smooth muscle cells and seeded endothelial cells. The study demonstrated cell viability, proliferation, and arrangement in the perfused channels comparable to traditional methods. The model allowed for the study of hemodynamic impact on biologically relevant anatomies, enabling experimental validation of the progression of vascular diseases such as atherosclerosis.
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| ID Code: | 249038 |
|---|---|
| Item Type: | QUT Thesis (PhD) |
| Supervisor: | Yarlagadda, Prasad, Li, Zhiyong, & Toh, Yi-Chin |
| Keywords: | Atherosclerosis, hemodynamics, vascular models, shear stress, 3D printing, GelMA hydrogel, tissue engineering, perfused cell culture, medical image segmentation, cardiovascular diseases |
| DOI: | 10.5204/thesis.eprints.249038 |
| Pure ID: | 171047593 |
| Divisions: | Current > QUT Faculties and Divisions > Faculty of Engineering Current > Schools > School of Mechanical, Medical & Process Engineering |
| Institution: | Queensland University of Technology |
| Deposited On: | 14 Jun 2024 05:40 |
| Last Modified: | 14 Jun 2024 05:40 |
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