Determination of the effect of JO146, a CtHtrA inhibitor, on the chlamydial developmental cycle and persistence
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Vanissa Ong Thesis (PDF 5MB) |
Description
The role of Chlamydia trachomatis HtrA (CtHtrA) for the growth and pathogenesis of this organism is presented. Inhibition of CtHtrA led to loss of infectious progeny in Chlamydia, particularly during heat stress or recovery from penicillin persistence. Isolation of CtHtrA inhibitor resistant mutants identified positive selection for mutants in fatty acid related pathways. Importantly, HtrA inhibition was effective against clinical isolates of C. trachomatis. Thus the findings combined indicate that CtHtrA is an important chlamydial growth factor that has the potential to be targeted for the development of anti-chlamydial drugs in the future.
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| ID Code: | 89931 |
|---|---|
| Item Type: | QUT Thesis (PhD) |
| Supervisor: | Huston, Willa & Beagley, Kenneth |
| Additional Information: | The Faculty has embargoed this thesis until 3rd November 2016. |
| Keywords: | Chlamydia trachomatis, intracellular pathogen, clinical isolate, HtrA, protease, inhibitor, mutants, developmental cycle |
| Divisions: | Past > QUT Faculties & Divisions > Faculty of Health Past > Institutes > Institute of Health and Biomedical Innovation Current > Schools > School of Biomedical Sciences |
| Institution: | Queensland University of Technology |
| Deposited On: | 16 Feb 2016 02:36 |
| Last Modified: | 29 Nov 2017 14:42 |
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