Bioengineered textiles with peptide binders that capture SARS-CoV-2 viral particles
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Description
The use of personal protective equipment (PPE), face masks and ventilation are key strategies to control the transmission of respiratory viruses. However, most PPE provides physical protection that only partially prevents the transmission of viral particles. Here, we develop textiles with integrated peptide binders that capture viral particles. We fuse peptides capable of binding the receptor domain of the spike protein on the SARS-CoV-2 capsid to the cellulose-binding domain from the Trichoderma reesei cellobiohydrolase II protein. The hybrid peptides can be attached to the cellulose fibres in cotton and capture SARS-CoV-2 viral particles with high affinity. The resulting bioengineered cotton captures 114,000 infective virus particles per cm2 and reduces onwards SARS-CoV-2 infection of cells by 500-fold. The hybrid peptides could be easily modified to capture and control the spread of other infectious pathogens or for attachment to different materials. We anticipate the use of bioengineered protective textiles in PPE, facemasks, ventilation, and furnishings will provide additional protection to the airborne or fomite transmission of viruses.
Impact and interest:
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ID Code: | 240515 | ||||||||||||
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Item Type: | Contribution to Journal (Journal Article) | ||||||||||||
Refereed: | Yes | ||||||||||||
ORCID iD: |
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Additional Information: | Acknowledgements: The authors thank Dr Christopher Doropoulos (Commonwealth Scientific and Industrial Research Organisation, Australia) for his help on absorption data model fit. We also thank Professor David Baker from the University of Washington for kindly providing the antiviral peptide sequences prior to publication. This work was funded by the Centre for Agriculture and Bioeconomy and the Centre for a Waste Free World, Queensland University of Technology. We also acknowledge the Central Analytical Research Facility, operated and funded by Queensland University of Technology (QUT), and the financial support of the Australian Research Council Centre of Excellence in Synthetic Biology. Part of the figures was created with BioRender.com. L.N. is supported by QUT and the CSIRO Synthetic Biology Future Science Platform. | ||||||||||||
Measurements or Duration: | 9 pages | ||||||||||||
DOI: | 10.1038/s43246-022-00278-8 | ||||||||||||
ISSN: | 2662-4443 | ||||||||||||
Pure ID: | 136358274 | ||||||||||||
Divisions: | Current > Research Centres > Centre for Agriculture and the Bioeconomy Current > Research Centres > Centre for Immunology and Infection Control Current > QUT Faculties and Divisions > Academic Division Current > QUT Faculties and Divisions > Faculty of Science Current > Schools > School of Biology & Environmental Science Current > QUT Faculties and Divisions > Faculty of Health Current > Schools > School of Biomedical Sciences |
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Funding Information: | The authors thank Dr Christopher Doropoulos (Commonwealth Scientific and Industrial Research Organisation, Australia) for his help on absorption data model fit. We also thank Professor David Baker from the University of Washington for kindly providing the antiviral peptide sequences prior to publication. This work was funded by the Centre for Agriculture and Bioeconomy and the Centre for a Waste Free World, Queensland University of Technology. We also acknowledge the Central Analytical Research Facility, operated and funded by Queensland University of Technology (QUT), and the financial support of the Australian Research Council Centre of Excellence in Synthetic Biology. Part of the figures was created with BioRender.com. L.N. is supported by QUT and the CSIRO Synthetic Biology Future Science Platform. | ||||||||||||
Copyright Owner: | 2022 The Authors | ||||||||||||
Copyright Statement: | This work is covered by copyright. Unless the document is being made available under a Creative Commons Licence, you must assume that re-use is limited to personal use and that permission from the copyright owner must be obtained for all other uses. If the document is available under a Creative Commons License (or other specified license) then refer to the Licence for details of permitted re-use. It is a condition of access that users recognise and abide by the legal requirements associated with these rights. If you believe that this work infringes copyright please provide details by email to qut.copyright@qut.edu.au | ||||||||||||
Deposited On: | 14 Jun 2023 01:48 | ||||||||||||
Last Modified: | 19 Jul 2024 09:52 |
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